Yotsubato
Spoiler warning: Plot or ending details follow.
Yotsuba To! (よつばと!) is a manga series by Azuma Kiyohiko, the creator of Azumanga Daioh. The series centers around the antics of Yotsuba, a six or seven year old girl who is energetic, cheerful, curious, strange and quirky; in fact, she's so strange and quirky that even her own father calls her a weirdo. She's also completely ignorant about a large number of things you'd expect a child of her age to know about, among them doorbells, escalators, and even playground swings; this not only adds to her weirdness, but also allows for humorous stories where she first learns about and/or misunderstands these everyday things.
"Yotsuba To!" means "Yotsuba And!", which comes from the fact that the title of every chapter/issue of the manga is of the form "Yotsuba and Something". The name "Yotsuba" (四葉) can be translated as "Four Lobes/Leaves", referring to Yotsuba's four ponytails.
