Recent Articles

Yohimbine

Synonyms: Yohimbin, Johimbine, Yohimbinum, Quebrachin, Aphrodin, Corynine, Yohimvetol, Hydroergotocin.

Chemical name: 17-alpha-hydroxy-yohimban-16-alpha-carboxylic acid methyl ester

Chemical formula: C₂₁H₂₆N₂O₃.

Molecular weight: 354.44 g/mol (free base, commercially available as its hydrochloride salt with a molecular weight of 390.90 g/mol).

Molecular structure:

See also: .

Yohimbine is the principal alkaloid from the bark of the West-African tree Pausinystalia yohimbe Pierre (formerly Corynanthe yohimbe), family Rubiaceae (Madder family) (see and ). There are 31 other yohimbane alkaloids found in Yohimbe.

Yohimbine is a selective competitive alpha2-adrenergic receptor antagonist and is used for treating erectile dysfunction. It is also used as a weight loss supplement as it increases Norepinephrine (noradrenaline) levels.

Higher doses of oral Yohimbine create numerous side effects such as rapid heart rate, high blood pressure, and overstimulation. Yohimbine is also used clinically to produce anxiety.

Some internet shops even sell expensive formulations of Yohimbine for percutaneous delivery to effect a local reduction of adipose tissue. From a pharmaceutical standpoint this seems highly unlikely and no evidence whatsoever is presented.

For a good review read this .

References