Urea cycle
The Urea Cycle is a cycle of biochemical reactions occurring in many animal organisms that produces urea from ammonia.
Urea is much less toxic than ammonia, therefore organisms which can't easily and quickly remove ammonia usually have to convert it to some other substance, like urea or uric acid. Insufficiency of the urea cycle occurs in some genetic disorders (inborn errors of metabolism), and in liver failure. The result in liver failure is accumulation of nitrogenous waste, mainly ammonia, which leads to NH3 + CO2 + 2 ATP → carbamoyl phosphate + 2 ADP + Pi (catalyzed by carbamoyl phosphate synthetase)
Summary reaction:
