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US 49 is a north-south United States highway. It was at the junction of Highway 49 and Highway 61 that blues singer Robert Johnson is said to have sold his soul to the Devil.
As of 2004, the highway's northern terminus is in Piggott, Arkansas at an intersection with US 62. Its southern terminus is in Gulfport, Mississippi at an intersection with US 90. The reported distance (unconfirmed) is 516 miles.
As of 2004, US 49E has a northern terminus in Tutwiler, Mississippi. It rejoins US 49 at Yazoo City, Mississippi. While the main line of US 49 passes through Indianola, US 49E veers to the east to serve Greenwood.
The highway passes through the following states: