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U.S. Highway 278 is a spur of U.S. Highway 78. It currently runs for 1,074 miles from Hilton Head Island, South Carolina to Wickes, Arkansas at U.S. Highway 59. It passes through the states of South Carolina, Georgia, Alabama, Mississippi, and Arkansas. It goes through the cities of Augusta, Georgia, Atlanta, Georgia, Gadsden, Alabama, and Tupelo, Mississippi.
List of United States Highways