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A topic-prominent language is one that organizes its syntax so that sentences have a topic-comment (or theme-rheme) structure, where the topic is the thing being talked about (predicated) and the comment is what is said about the topic. This structure is independent of the syntactic ordering of subject, verb and object, and may be marked by word order (typically mentioning the topic first thing in the sentence, and then the comment), or by explicit morphology (as in Japanese with the clitic particle wa).
The difference between topic-prominent languages and non-topic-prominent languages is that topic marking is done systematically in the former, while the latter resort to various idiosyncratic means for topicalization (see "Topic" for English examples).
Examples of topic-prominent languages are the Chinese languages, Japanese and Korean.