Succinyl CoA

Succinyl-Coenzyme A, generally abbreviated as Succinyl-CoA is a combination of succinic acid and coenzyme A.

Source

It is an important intermediate in the citric acid cycle, where is it synthetised from α-Ketoglutarate by α-ketoglutarate dehydrogenase through decarboxylation. During the process, coenzyme A is added.

Fate

It is converted into succinate through the hydrolytic release of coenzyme A by succinyl-CoA synthetase.

Another fate of succinyl-CoA is porphyrin synthesis, where succinyl-CoA and glycine are combined by ALA synthase to form δ-aminolevulinic acid (dALA).