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The Space Pope is a minor character in Fox's Futurama animated TV series, which is set in the 30th century. The Space Pope (Crocodylus pontifex) is the head of the religion known as space Catholicism. Space Catholicism discourages love between robots and humans.
Analogous to the popular retort "is the Pope Catholic?" (in reply to a question whose answer is clearly in the affirmative) is the line from the show "is the Space Pope reptilian?".