Spa

Spondyloarthropathies are a group of related inflammatory joint disease associated with the MHC class I molecule HLA-B27. Subgroups (with increased HLA-B27 frequency) are:

ankylosing spondylitis (AS, 90%),
reactive arthritis (ReA)/Reiter's syndrome (RS, 80%),
enteropathic arthritis associated with inflammatory bowel disease (IBD, 70%),
psoriatic arthritis (PsA, 60%),
isolated acute anterior uveitis (AAU, iritis or iridocyclitis, 50%), and
undifferentiated SpA (USpA, 20-25%).

Whipple disease and Behçet disease may also be linked to HLA-B27.

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