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The Rio Grande Valley is the southernmost tip of Texas. It is along the northern bank of the Rio Grande river.
The region is made up of four counties: Starr County, Hidalgo County, Willacy County, and Cameron County.
Major cities include Brownsville, Harlingen, McAllen, and Weslaco.
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| Regions: Central Texas | East Texas | North Texas | Northeast Texas | Rio Grande Valley | Texas Hill Country | Texas Panhandle | Llano Estacado | West Texas | Houston Metropolitan Area | Dallas/Fort Worth Metroplex | |
| Largest Metropolitan areas: Abilene | Amarillo | Austin- San Marcos | Beaumont- Port Arthur | Brownsville- Harlingen- San Benito | Bryan- College Station | Corpus Christi | Dallas-Fort Worth | El Paso | Houston-Galveston-Brazoria | Killeen- Temple | Laredo | Longview- Marshall | Lubbock | McAllen- Edinburg- Mission | Odessa-Midland | San Angelo | San Antonio | Sherman- Denison | Texarkana | Tyler | Victoria | Waco | Wichita Falls | |
| See also: List of counties in Texas |