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Quad is a latin prefix meaning four. (Tetra is the Greek equivalent).
The word quad can mean a number of things:
In the language used by trade negotiators, the 'quad' are the countries of the United States, Japan and Canada, plus the European Union. These four economies are responsible for around 61% of world imports by value, and 71% of world exports, and so they have considerable clout within the World Trade Organisation.