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Pinky and the Brain are cartoon characters from the animated television series Animaniacs. Later they starred in their own cartoon show called Pinky and the Brain and even later in Pinky, Elmyra and The Brain.
The two are genetically enhanced lab mice who reside in a cage in the Acme Labs research facility. Each week sees Brain come up with a new plan for the two (led by him) to take over the world, which ultimately ends in failure. In common with many other Animaniacs shorts, many episodes are in some way a parody of something else - usually a film.
The Brain bears a resemblance to Orson Welles, especially in voice (voiced by Maurice LaMarche). He is highly intelligent and develops Rube Goldbergian plans for global domination. His tail is bent, like a staircase, and his head is large and wide, supposedly housing his abnormally large brain. He is coldly emotional and speaks in a deadpan manner. Nevertheless, Brain has a very subtle sense of humor, and has even fallen in love once, with Billie, a rather dippy girl mouse with a Queens accent. Intellectually, Brain sees his inevitable rise to power as beneficial to improving the world rather than being pure egotism.
The characteristics of the Brain would lead one to believe that he is more suited to be an antagonist rather than a protagonist, but the series tends to present him as a quixotic fellow striving for greatness against the odds, evoking sympathy from the audience and causing viewers to like him, despite his seemingly evil plans for world domination. Unfortunately for him, his schemes are always doomed to failure at the hands of one or more of several common mistakes: Pinky does something dumb to queer the deal, or Brain gravely under/overestimates the masses' intelligence.
Pinky (voiced by Rob Paulsen) is another genetically modified mouse who shares the same cage at Acme Labs but is substantially less bright. He speaks with a heavy accent, possibly Australian or cockney English (the actor that voiced Pinky was a fan of Monty Python). He frequently says nonsense interjections like "Narf", "Zort" and "Poit". Although also an albino lab mouse like the Brain, he has a straighter tail and a severe overbite. Pinky is more open-minded than the Brain - perhaps excessively so given that his off-and-on again girlfriend is a horse and he thinks a spool of thread is his little sister - and generally friendlier. His parents are also nimrods; perhaps it's genetic.
The duo have also matched wits with Snowball, a hamster (voiced by Roddy MacDowall) with similar genetic modifications and lust for power, but with less benevolent goals.
The catchphrase used at the start of almost every episode is: