Phospholipase
A phospholipase is an enzyme that converts phospholipids into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D.
Phospholipase A
Phospholipase A2 catalyses the first step in the formation of arachidonic acid, the precursor of all eicosanoids (leukotrienes, prostaglandins).
The PDB code for phospolipase A2 is ; the EC code is EC 3.1.1.4.
Phospholipase B
- To be written
Phospholipase C
- To be expanded
(Bacillus Cereus: PDB , EC 3.1.4.3)
Phospholipase C is a key enzyme in phosphatidyl inositol metabolism. It is activated by either G proteins (making it part of a G protein-coupled receptor signal transduction pathway) or by transmembrane receptors with intrinsic or associated tyrosine kinase activity. It converts phosphatidyl inositol to either inositol triphosphate or diacylglycerol.
