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Nestorius (c.386 - c.451) was Patriarch of Constantinople (April 10, 428 - June 22, 431). He received his clerical training as a pupil of Theodore of Mopsuestia in Antioch and gained a reputation for his sermons that led to his enthronement by Theodosius II as Patriarch following the death of Sisinius I in 428 C.E..
His antagonist was Cyril, bishop of Alexandria. The Christological debate was in the forefront, as it has been reported, but there was also a political struggle between the supporters of the See of Alexandria and the See of Antioch, that is too easily overlooked. Rival apostolic lines of succession were established, and the development of the concept of patriarchal primacy pitted Western Alexandria against Eastern Antioch. Whatever the occasion of the theological debate, it was also an expression of Pope Celestine I siding with Cyril against Nestorius, Patriarch of Constantinople.
The theological debate centered on the novel title of "mother of God" (Theotokos) for the Virgin Mary, which Nestorius did not recognize, preferring in his sermons, "mother of Christ" (Christotokos), on the grounds that the former title compromised Jesus Christ's divinity. His views were opposed by Cyril, and the Emperor was eventually induced to convoke a council, sited at Ephesus, which was a special seat for the veneration of Mary, where the theotokos formula was popular. Cyril took charge of the Council of Ephesus (431), opening debate before the contingent from Antioch could arrive, deposed him and labelled him a heretic. In Nestorius' own words,
In the following months, seventeen bishops who supported his doctrine were removed from their sees, and his principal supporter, John, patriarch of Antioch succumbed to Imperial pressure around March, 433 and abandoned Nestorius. At the end, Theodosius II, who had supported Nestorius' appointment, bowed to the influence of his sister Pulcheria to issue an Imperial edict (August 3, 435) that exiled Nestorius to a monastery in the Great Oasis of Hibis (al-Khargah), in Egypt, securely within the diocese of Cyril. In East and West, Nestorius' writings were burnt wherever they could be found. Hence they survive mainly in Syriac.
This led to a split within the church and to the creation of separate Nestorian churches that flourished in the Middle East and central Asia.
After 1500 years stigmatized as a heretic, a book written by Nestorius was discovered in 1895, known as the Bazaar of Heracleides, written towards the end of his life, in which he explicitly denies the heresy for which he was condemned, instead, affirming of Christ "the same one is twofold" - an expression similar to the formulation of the Council of Chalcedon.)