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In biochemistry, a metalloprotein is a generic term for a protein that also contains a metal cofactor. The metal may be an isolated ion or may be coordinated with an nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters.
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