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Maprotiline (Deprilept®; Ludiomil®; Psymion®) is an antidepressant drug from the tetracyclic antidepressant drug group.
Maprotiline is a norepinephrine reuptake inhibitor. This increases the amount of norepinephrine available to synapses which maprotiline is active in. Interestingly for an antidepressant medication, it has no known effect on serotonin, a neurotransmitter widely thought to be involved in mood regulation and therefore clinical depression.
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