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Lipinski's Rule of Five

Christopher A. Lipinski formulated a so-called rule of 5 as criteria for the ability of a compound to be absorbed or permeate through biological barriers, the first of the ADME-Tox criteria for a potential drug. The rule derives its name from the fact that the relevant cutoffs are all multiples of 5:

• not more than 5 H-bond donors
• no more the 10 H-bond acceptors (notably N and O)
• molecular weight under 500
• LogP under 5

References

• CA Lipinski, Adv. Drug Del. Rev. 1997, 23, 3