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A translation of the Latin Inquisitor Generalis, meaning the leading official of an Inquisition. The most famous Inquisitor General of them all was probably the Spanish Dominican Tomás de Torquemada.
The Grand Inquisitor is also the name given to a section of The Brothers Karamazov, a literary work by the Russian author and philosopher Fyodor Dostoevsky. The central character of the piece is a grand inquisitor who arrests Jesus himself.