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The Four Horsemen of the Apocalypse are mentioned in the Bible in chapter six of the Book of Revelation. The four horsemen are traditionally named War, Famine, Pestilence, and Death.
The white color of the first horse could mean victory, because generals of that time often rode white horses after they had won a battle or war. The crown that its rider wore was a kind of prize awarded for service in a war. The bow that he carried could be a symbol of an enemy at that time, the Parthians, who were famous for their archery. The red color of the second horse could mean bloody war, and the sword held by the rider symbolizes war and violence. The black color of the third horse could be a symbol of death and famine. Its rider was holding a scale, which means scarcity of food, higher prices, and famine. The pale greenish color of the 4th horse means fear, sickness, decay, and death. The imagery of the four horses is adapted from a passage in Zechariah.
From the King James Version of the Bible, verses 1 to 8:
The "Four Horsemen of Notre Dame" were the legendary backfield of Notre Dame's 1924 football team, namely quarterback Harry Stuhldreher, fullback Elmer Layden and halfbacks Jim Crowley and Don Miller. They were so dubbed by sports writer Grantland Rice in his account of the Notre Dame-Army game October 18, 1924, at the Polo Grounds in New York City: "Outlined against a blue-gray October sky, the Four Horsemen rode again. In dramatic lore, they are known as famine, pestilence, destruction and death. These are only aliases. Their real names are Stuhldreher, Miller, Crowley and Layden."
Four Horsemen of the Apocalypse is the title of a 1961 film by Vincente Minnelli and of a lesser-known 1921 film by Rex Ingram. The Vincente Minnelli version has been selected for preservation in the United States National Film Registry. Both are based on a novel by Vicente Blasco Ibáñez about World War I.
Johnny Cash - The Man Comes Around - Lyrics and Song here - http://www.hit-country-music-lyrics.com/johnnycashlyrics-mancomesaround.html
The Clint Eastwood film Pale Rider makes multiple references to the verse above.
The novel Good Omens, by Terry Pratchett and Neil Gaiman, includes an appearance by the four horsemen - Death, War, Famine, and Pollution (Pestilence having retired) - who have, in deference to changing times, traded in their horses and formed a motorcycle gang.
In the universe of Marvel Comics, Apocalypse is a supervillain, an enemy to the X-Men, and whenever he resurfaces he typically converts four mutants into his Horsemen, including Death, War, Famine, and Pestilence. The most notable of these was Warren Worthington III, the X-Man once known as Angel. After Worthington's wings were cut off in the Mutant Massacre, Apocalypse surgically grafted mechanical wings to his body and dyed his skin blue, transforming him into the horseman Death. Worthington soon threw off Apocalypse's influence and rejoined the X-Men as Archangel. He has since returned to the name Angel.
There is an early episode of the television show, Charmed, where the horsemen fail to end the world.
The web comic End Times by Bailey Piling and Philip Rigby portrays four young girls who died on the same day as becoming the four horsewomen. Each of the girls died in a way that pertains to the name she accquires, for instance, the girl who becomes Famine died of anorexia, and the girl who becomes Pestilence died of an exotic disease.
The famous four horsemen turned up in an episode of The Young Ones (television series), and lamented that they were tired of playing Travel Scrabble.
Metallica's 1983 CD "Kill 'Em All" features a song called "The Four Horsemen".
The computer game Nethack features Famine, Pestilence and Death as the final enemies of the player character, himself assimilated to War.
There is a representation of the four horsemen of the apocalypse (as cowboys) in Episode 3, Series 6 of the British television comedy, Red Dwarf. The four horsemen are used as the visual representation of a computer virus within a virtual reality game. The fight between the horseman and the main characters of Red Dwarf represents the attempt to destroy the virus. Anti-virus software is represented as a pair of doves.