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Drusilla is a fictional character that appeared in the television series Buffy the Vampire Slayer and Angel.
Spoiler warning: Plot or ending details follow.
Drusilla was a young woman with a gift that Angelus referred to as "the sight." Angelus became obsessed with Drusilla 200 years ago and plagued her and her family for several years. It was during this time that Angelus eventually drove her to madness (this would remain permanent throughout the two series). She was then "sired" (that is, transformed into a vampire) by Angelus. She later "sired" Spike.
When Angelus was cursed with a soul and became Angel, Spike and Drusilla then went their separate ways from Darla and Angel. Drusilla and Spike were introduced in "School Hard" as they plotted the downfall of Buffy Summers but never succeeded.
When Angel reverted to his evil self after a moment of perfect happiness (sexual intercourse leading to an orgasm, i.e. the moment) with Buffy, Spike became jealous of Angel's increasing interest in Drusilla. Spike and Drusilla began to drift apart. Their alienation from one another resulted in their leaving Sunnydale, after Spike choked Drusilla unconscious while Buffy and Angel fought.
It wasn't until season five of Buffy and season two of Angel that Drusilla reappeared in flashbacks, plotting with Darla to return Angel to his former evil self before returning to Sunnydale to resume her relationship with Spike, despite the fact that Spike had once threatened to stake her and now loved Buffy.
Drusilla's madness (as exhibited, especially, in her often-strange dialogue) makes her an interesting character and shows how evil she can be. Her speech is often peppered with non sequiturs like "Spike, do you love my insides? The parts you cannot see?" British before her transformation to a vampire, Drusilla speaks with a thick Cockney accent. Drusilla's part in the Buffyverse is mainly through flashbacks, only appearing in the present in Seasons 2 and 5 of Buffy and Season 2 of Angel. Her Buffyverse episode catologue is as follows;
BUFFY THE VAMPIRE SLAYER
SEASON TWO (1997-1998)
SEASON FIVE (2000-2001)
SEASON SEVEN (2002-2003)
ANGEL
SEASON TWO (2000-2001)
SEASON FIVE (2003-2004)
Drusilla is portrayed by actress Juliet Landau.