Desloratadine
Desloratadine is a drug used to treat allergies. It is sold under brandnames such as Clarinex and Aerius. It is an active metabolite of loratadine,which is also on the market.
Descarboethoxyloratadine
|
| 8-chloro-6,11-dihydro-11-(4-piperdinylidene)- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine
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| Molecular Weight
| 310.82
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| Empiric Formula
| C19H19ClN2
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| ATC code
| R06AX27
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| Metabolism
| Liver
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| Pregnancy category
| C (USA)
? (Aus)
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Available forms
Desloratadine is available as tablets and oral suspension.
Mechanism of action
Desloratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action. It has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system. It is 10-20 times more potent antihistamine than loratadine.
Pharmacokinetics
Desloratadine is rapidly absorbed from the gastro-intestinal tract. Desloratadine is moderately bound to plasma proteins (85%). The half-life of desloratadine is on average 28 hours. About 40% is excreted as conjugated metabolites into the urine and similar amount into the feces. Traces of unmetabolised desloratadine can be found in the urine.
Side effects
Most common side-effects are fatigue, drowsiness, dry mouth, headache, and gastrointestinal disturbances.
