Clopidogrel
Clopidogrel bisulfate
|
| methyl (+)-(S)-α-(2-chlorophenyl)-6, 7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate sulfate (1:1) |
| Molecular Weight |
419.9 |
| Empiric Formula |
C16H16Cl NO2S·H2SO4 |
| Metabolism |
Liver |
| Excretion |
Renal |
Clopidogrel, which is often prescribed under the brand name Plavix ® (clopidogrel bisulfate; produced by Bristol-Myers Squibb and ), is a potent oral antiplatelet agent often used in the treatment of coronary artery disease, peripheral vascular disease, and cerebrovascular disease.
The mechanism of action of clopidogrel is irreversible inhibition of the adenosine diphosphate (ADP) receptor of platelet cell membranes. This prevents aggregation of platelets.
Two hours after a single dose of oral Plavix®, platelet inhibition can be demonstrated.
Clopidogrel is Thrombotic thrombocytopenic purpura (TTP) (Incidence: 4/1,000,000 patients treated)
- Hemorrhage - The incidence of hemorrhage may be increased by the co-administration of aspirin.
- Gastrointestinal Hemorrhage (Incidence: 2.0%)
- Cerebral Hemorrhage (Incidence: 0.1 to 0.4%)
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