Bradykinin
Bradykinin is a protein of the kinin group of proteins and consists of 9 amino acids. The kininogenase kallikrein makes bradykinin by proteolytic cleavage of its kininogen precursor, high molecular weight-kininogen (HMWK).
It is a potent vasodilator, causes contraction of non-vascular smooth muscle, and increased vascular permeability and also causes pain.
It has similar actions to that of histamine.
The amino acid sequence of bradykinin is: arg - pro - pro - gly - phe - ser - pro - phe - arg.
