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The Second Battle of Lepanto, also known as the Battle of Modon happened in 1500, as part of the 1499-1503 Turkish-Venetian Wars between the Ottoman Empire and the Venetians. The Ottomans, who had won the First Battle of Lepanto the previous year, were again victorious under Admiral Kemal Re'is.
Lepanto was also the scene of battles in 429 BC, and 1571. See Battle of Lepanto.