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Antonia Major (Latin for "the older") (b. 39 BC) was a daughter of Mark Antony and Octavia, the sister of Augustus Caesar.
She married Lucius Domitius Ahenobarbus. Their son Gnaeus Domitius Ahenobarbus married Agripinilla, and their son was the emperor Nero. Antonia and Ahenobarbus's daughter Domitia Lepida married Valerius Messala Barbatus, and their daughter Messalina married the emperor Claudius and bore his two children.
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