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Alfred E. Neuman is most well known as the fictional mascot of Mad magazine. His likeness has graced the cover of most monthly issues. He first appeared in November 1954 on the cover of The Mad Reader, a collection of reprints from earlier issues. Neuman has appeared as Santa Claus, Darth Vader, George Washington and Uncle Sam, to name a few. Although Neuman appeared on the cover, the name did not become associated with the image until 1956. He ran for president with the slogan, "You could do worse, and always have!"
Along with his face, MAD also features a humorous quote of him in every issue.
The likeness of Neuman probably derived from an early 20th century popular newspaper comic strip, "The Yellow Kid". Many advertisements from that era included the likeness and his famous slogan, "What, me worry?" When Mad magazine was sued for copyright infringement, one defense it used was that it had copied the picture from materials dating back to 1911.