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Whipple's disease is a rare disease caused by the bacteria Thropheryma Whipplei. It is characterised by arthritis, malabsorption, and a number of other symptoms, most notably intestinal lipodystrophy (accumulation of fatty deposits in lymph nodes of the intestine).
It was first described by George Hoyt Whipple in 1907: Whipple GH. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acid in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp 1907;18:382-93.
| Halitosis - Nausea - Vomiting - GERD - Achalasia - Esophageal cancer - Esophageal varices - Peptic ulcer - Abdominal pain - Stomach cancer - liver - pancreas - gallbladder - biliary tree |
| Hepatitis - Cirrhosis - NASH - Budd-Chiari syndrome - Hepatocellular carcinoma - Pancreatitis - Pancreatic cancer - Gallstones - Cholecystitis |
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Diseases of the small intestine |
| Peptic ulcer - Malabsorption (e.g. celiac disease, lactose intolerance, fructose malabsorption, Whipple's disease) - Lymphoma |
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Diseases of the colon |
| Diarrhea - Appendicitis - Diverticulitis - Diverticulosis - IBD (Crohn's disease and Ulcerative colitis) - Irritable bowel syndrome - Constipation - Colorectal cancer - Hirschsprung's disease - Pseudomembranous colitis |
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