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Under the current constitution, the Prime Minister of Cameroon is a relatively powerless executive. While the Prime Minister is officially appointed to be the head of government, the President retains most of the executive power and can fire the Prime Minister at will.
The position has existed in the eastern part of Cameroon since independence from France in 1960. When the western part gained independence from the British in 1961, the two halves of the Cameroon federation maintained their autonomy and each had a separate Prime Minister. In 1972, Cameroon became a unitary state and the position of Prime Minister was temporarily unfilled. In 1975, Paul Biya was appointed Prime Minister for all of Cameroon. After his succession to the Presidency, Biya refused to appoint a Prime Minister from 1984 to 1991.
| 1. | Ahmadou Ahidjo | 1 January 1960 | 15 May 1960 |
| 2. | Charles Assalé | 15 May 1960 | 19 June 1965 |
| 3. | Vincent de Paul Ahanda | 19 June 1965 | 20 November 1965 |
| 4. | Simon Pierre Tchoungui | 20 November 1965 | 2 June 1972 |
| 1. | John Ngu Foncha | 1 October 1961 | 13 May 1965 |
| 2. | Augustine Ngom Jua | 13 May 1965 | 11 January 1968 |
| 3. | Salomon Tandeng Muna | 11 January 1968 | 2 June 1972 |
| 1. | Paul Biya | 30 June 1975 | 6 November 1982 |
| 2. | Bello Bouba Maigari | 6 November 1982 | 22 August 1983 |
| 3. | Luc Ayang | 22 August 1983 | 25 January 1984 |
| *. | Position vacant | 25 January 1984 | 26 April 1991 |
| 4. | Sadou Hayatou | 26 April 1991 | 9 April 1992 |
| 5. | Simon Achidi Achu | 9 April 1992 | 19 September 1996 |
| 6. | Peter Mafany Musonge | 19 September 1996 | Current |