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The Cayuga tribe (Guyohkohnyo or the People of the Great Swamp) was one of the five original constituents of the Iroquois, a confederacy of Indians in New York. The Cayuga homeland lay in the Finger Lakes region between their league neighbors, the Onondaga and the Seneca.
Due to many attacks on American colonists during the American Revolution, the punitive Sullivan Expedition devastated the Cayuga homeland. Survivors fled to other Iroquois tribes or to Canada.