August 13 - Treaty of Noyon - Peace between France and Spain. Francis recognizes Charles's claim to Naples, and Charles recognizes Francis's claim to Milan.
August 24 - Battle of Merj-Dabik. The Ottomans defeat the Mameluks, who abandon Syria.
October 28 - Battle of Yaunis Khan. Turkish forces under the Grand Vizier Sinan Pasha defeat the Mameluks near Gaza.
December 4 - Treaty of Brussels - Peace between France and the Empire.